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AMITRIPTYLINE USES
Amitriptyline is used to treat symptoms of depression. Amitriptyline is in a class of medications called tricyclic antidepressants (mood elevators). It works by increasing the amounts of certain natural substances in the brain.

DIRECTIONS:
Amitriptyline comes as a tablet to take by mouth. It is usually taken one to four times a day. To help you remember to take Amitriptyline, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Amitriptyline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Your doctor will probably start you on a low dose of Amitriptyline and gradually increase your dose. It may take a few weeks or longer before you feel the full benefit of Amitriptyline. Continue to take Amitriptyline even if you feel well. Do not stop taking Amitriptyline without talking to your doctor. Stopping amitriptyline suddenly may cause withdrawal symptoms (upset stomach, headache, and lack of energy). Your doctor will probably decrease your dose gradually.

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POSSIBLE SIDE EFFECTS OF AMITRIPTYLINE
Amitriptyline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: upset stomach, vomiting, drowsiness, weakness or tiredness, excitement or anxiety, difficulty falling asleep or staying asleep, nightmares, restlessness, headaches, dry mouth, constipation, difficulty urinating, blurred vision, pain, burning, or tingling in the hands or feet, changes in sex drive or ability, excessive sweating, changes in appetite or weight, confusion, unsteadiness, Some side effects can be serious. Amitriptyline may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

AMITRIPTYLINE DRUG INTERACTIONS
Amitriptyline may block the antihypertensive action of guanethidine or similarly acting compounds.When amitriptyline is given with anticholinergic agents or sympathomimetic drugs, including epinephrine combined with local anesthetics, close supervision and careful adjustment of dosage are required. Paralytic ileus may occur in patients taking tricyclic antidepressants in combination with anticholinergic-type drugs.
Since amitriptyline, in combination with anticholinergic type drugs, may give rise to paralytic ileus, particularly in elderly or hospitalized patients, appropriate measures should be taken if constipation occurs in these patients.
Cimetidine is reported to reduce hepatic metabolism of certain tricyclic antidepressants.

AMITRIPTYLINE STORAGE
Keep Amitriptyline in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

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